Apr
23
2007

Asthma research involves response to chitin.

Chitin, a clue in understanding asthma.

Asthma linked to chitin: House dust mite.
Asthma linked to chitin: House dust mite.
Chitin is found in dust mites, cockroaches, insect eggs, shellfish, fungi, and intestinal worms. When researchers at Howard Hughes Medical Institute (HHMI) aerosolized purified chitin and sprayed it into the lungs of laboratory mice, it caused a rapid and intense immune response.

The researchers found that when mice have more AMCase than normal, the immune response to chitin is greatly reduced. Locksley believes that AMCase, a chitinolytic enzyme, attenuates the chitin-induced innate immune response by degrading the chitin. This removes the stimulus for further eosinophil and basophil recruitment more rapidly and halts the allergic response. Howard Hughs Medical Institute research news

Acidic mammalian chitinase, AMCase, breaks down chitin.

Our immune system can remember what previous irritants look like and can respond with a customized defense. This ability explains why vaccinations are effective. Sometimes the defense (or allergic response) overwhelms other body functions (like in an asthma attack). Findings about chitin and AMCase may help explain the extremely high rates of asthma—as high as 25 percent—found in previously asymptomatic workers in shellfish processing plants.

Read about new asthma research online.

Richard Locksley's laboratory is investigating the biological mechanisms underlying asthma and hopes to provide new ways of preventing and possibly treating it. The new findings are published in the April 22, 2007, online version of the journal Nature You can read their research abstract here.

Your Comments, Thoughts, Questions, Ideas

Anonymous's picture
Anonymous says:

Asthma is an emotional disease. It has been cured with hypnosis since at least the 1950's. See Diamond, H.H. Hypnosis in Children: The Complete Cure of 40 Cases of Asthma. Am. J. Clin. Hypn. 1959; 1 124-29.

And there are many more if you search PubMed for "hypnosis asthma".

posted on Mon, 04/23/2007 - 8:33pm
Anonymous's picture
Anonymous says:

Asthma can be emotional, but if you have suffered with Asthma from birth you will realize that there are a lot of other triggers, exercise, dust mites, and weight are just a few, Some of which up till now have been unexplained, any new research to Asthma has been long overdue.
I look forward to a permanent cure for all Asthma sufferers

posted on Fri, 04/27/2007 - 2:15am
drcyrus's picture
drcyrus says:

subject: if you was an astma patient what do u wish?
i think i wish; there was a medicine that with once use , i forever to be free of this disease . objects: 1. genetic (certain gen eating) , 2. use from microelement that forevere change the behavior of gates in the cell membranes 3. drinking the urine of camel 4. by surgery, selective cut the parasympatic nerve divisions (of vagus) which are efferent and afferent of bronchioles 5.polens

polen sometime are the eatiology of asthma: polen
polen sometime are the eatiology of asthma: polenCourtesy it is mine

posted on Fri, 12/25/2009 - 10:04am

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