Sep
25
2007

Blood test detects early lung cancer

Blood test for detecting lung cancer

Lung cancer is a killer
Lung cancer is a killer
A simple blood test that identifies early lung cancer before it has had a chance to spread could save lives by alerting doctors to the need for treatment. Lung cancer is responsible for 1.3 million deaths each year worldwide. Detecting lung tumors in the earliest stages now looks promising.

HAAH protein is an indicator

Mark Semenuk, a researcher at Panacea Pharmaceuticals in Gaithersburg, Maryland, US, presented the lung cancer test at a meeting in Atlanta, Georgia, US, on molecular diagnostics in cancer therapeutic development run by the American Association for Cancer Research. Semenuk and colleagues developed the test, which measures levels of a protein called human aspartyl beta-hydroxylase (HAAH) in the blood.

Scientists believe HAAH migrates to the surface of a cell to help make it receptive to chemical cues that promote growth. Laboratory findings also suggest that if the protein stays too long at the cell's surface, it may fail to mature properly, and can become cancerous.

The test received approval for limited laboratory testing in July 2007, but the FDA has yet to approve a commercial version of the test.

In one experiment, they used this test to screen blood serum taken from 303 people, 160 of whom were known to have lung cancer at various stages of development. Their test accurately identified the presence of cancer in all but one of the patients with the disease.
In a second experiment, the team screened blood from a further 60 patients with lung cancer at several known stages of development. This included 15 people with stage 1 lung cancer – the earliest stage of this illness and at which point the cancer has not yet spread. All 60 samples tested positive for cancer, indicating that the test can reliably detect the illness early on. New Scientist

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Detection (99%), false positives (8%)

More than 3 nanograms of HAAH per milliliter of blood is considered to be abnormal. In the test, people with lung cancer had an average HAAH count of 34 ng/ml of blood. Although the HAAH levels for the rest of the group, which included 93 non-smokers and 50 smokers, were much lower, about 8 % of those without the cancer had more than 3 ng/ml, triggering a handful of false positive results.

Your Comments, Thoughts, Questions, Ideas

Anonymous's picture
Anonymous says:

Early detection of cancer saves lives, or as I often say, “Early detection-early survival.”
Thanks for this info.

posted on Sat, 10/06/2007 - 12:01am
Lola Whitchenhoff's picture
Lola Whitchenhoff says:

How can you know if you are going to have cancer.

posted on Sat, 10/06/2007 - 3:27pm
allysha's picture
allysha says:

iveget tested for cancer right this instant so u can survu

posted on Sat, 10/06/2007 - 3:28pm
Ray's picture
Ray says:

Just received the result of my LC Detect HAAH test. I tested less than 2.0 nanograms. Needless to say this is good news. A recent non-related CT scan detected a small (1 inch) lesion on my left lower lung. I am a non-smoker! Still you need to be sure something like this does not take you out. I am going to consult with my oncologist. Maybe retest in 3 or 4 months. Look up "best rated cancer clinics". Keep learning. Good health to all.

posted on Mon, 12/03/2007 - 9:00pm
ARTiFactor's picture
ARTiFactor says:

Thank you for your comment and the info about the LC Detect HAAH test (click to learn more).

posted on Mon, 12/03/2007 - 10:28pm
Donate Blood's picture

Sorry if I sound stupid. But I am wondering if this test is suggested when you are giving blood or taking blood? I know there is no conclusive proof to say that cancer can be transmitted by blood but when
the risk is that high and we have a simple methodology to verify if the blood is contaminated isn't it worth the effort?

posted on Sun, 06/27/2010 - 8:56am

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