Dec
31
2006

Diabetes breakthrough

Insulin pump: New hope for diabetics.
Insulin pump: New hope for diabetics.

Diabetes in 171 million (WHO)

My niece nearly died from diabetes complicactions just before Thanksgiving. Shortly after being diagnosed with child onset diabetes (type 1), she suffered toxic shock syndrome. Before eating her Thanksgiving meal she needed to get blood from her finger, measure her blood sugar, calculate the amount of insulin needed for the food she would eat, then inject the proper amount via a needle into her body.

At Christmas time I shared with her that perhaps within a few years, a cure for her diabetes would be available. In a breed of mice genetically predestined to develop diabetes, researchers discovered that

after just one injection of a neuropeptide called "substance P" the diabetes disappeared overnight and the mice remained diabetes-free for weeks, and even months in some cases.sickkids.ca

New model for diabetes cause (and cure)

This research is reported in the December 15 issue of the journal, Cell.
Scientists at a Toronto hospital found that malfunctioning pain neurons in the pancreas might be the cause of diabetes. This upsets conventional wisdom that Type 1 diabetes is caused by an auto-immune response.

“We started to look at nervous system elements that seemed to play a role in Type 1 diabetes and found that specific sensory neurons are critical for islet immune attack in the pancreas,” said Dr. Hans Michael Dosch, study principal investigator, senior scientist at SickKids and professor of Paediatrics and Immunology at the University of Toronto. “These nerves secrete insufficient neuropeptides which sustain normal islet function, creating a vicious circle of progressive islet stress.”

The researchers caution they have yet to confirm their findings in people, but say they expect results from human studies within a year or so. Any treatment that may emerge to help at least some patients would likely be years away from hitting the market. Canada.com-National Post

Your Comments, Thoughts, Questions, Ideas

Anonymous's picture
Anonymous says:

I cannot tell you how many times my daughter & I have heard 'there may be a cure soon" from well-meaning friends & relatives. By all means, stay on top of research and developments. Unfortuantely, the key words in the article you quote are "genetically predestined to develop diabetes", which means they are not yet diabetic. Most research & breakthroughs are in prevention, not a cure once it is diagnosed. Stem cell research, islet cell transplants, etc..all on the horizon. My daughter, when she was 4 was diagnosed 18 years ago with Type 1 diabetes and that was supposed to be, according to the American Diabetes Association, the decade for the cure. We are still waiting. It seems hers was broguht on by a virus that she caught from her cousin, a Cocksakie strain, commonly known as Hand, foot & mouth disease.
Within weeks of her catching that virus, she started developing symptoms of diabetes and within 3 months she was diagnosed with Type 1. She remarkably stayed in her honeymoon phase for over 1 year, putting out small amounts of insulin on her own. WE were so hopeful that something would happen, some kind of breakthrough, while she was still able to do this. Something to boost her output. Anything to strengthen her insulin production while she was still prodcuing it. Though there have been a few innovations to make her life easier these last 18 years, she still checks her blood with finger pokes 4x a day, & still has 3 to 4 injections of insulin a day. She refuses to get an implantable pump. Good luck, and at least your niece can lead a normal and healthy, yes healthy, life. She needs to take care of number 1 always and good control and healthy living are key to that. Take Care.

posted on Sat, 01/06/2007 - 5:26pm
Joe Schweitzer's picture
Joe Schweitzer says:

Likely years away from the market. Yep, thats what we expect from the diabetes market. Especially in the U.S.A.. I think we all know this will never happen with the total amount of money at stake for companies like Lilly, Roche, Bayer, Novo Nordisk A/S, and others. It will never happen. I would like to be the first to offer my body to help the test of this drug. I have been a type 1 diabetic for 23 years and have heard it all. I have taught and would like to teach more people with type 1 diabetes for the rest of my life. If you truly give one shot for the cure of this diease, the push back and collapse of the economy will be monumental. Surely the powers that be know this, but most of the diabetics in the world may not get it. I am tierd of hearing the "its great progress" speech from all the "so called doctors" that do not have this disease. I want to hear from someone that has this disease and lives with it everyday to tell me how to manage it. I have done so with some great success. No Dr. that does not have this disease can tell me how i feel with it or what to do when sometihing makes me feel incredibly bad. Oooooh they can tell me what the cells are doing or what the Insulin is doing after sooo long, but ther is no way to tell me what i feel or how it fells in my body when anything happens. This is the first letter i have ever written in my life about my disease and hope to write more. I want to continue to teach people and listen and help but i am not sure how to get my message out to the millions that need it. If this is the "cure", let it happen. I am first!!!!!!!!!!!!!!!!, to get on the list if you wish. But, I will probably Die before this really takes place, unless we all take a stand and get this horrible disease cured.

posted on Sat, 01/06/2007 - 9:23pm
Anonymous's picture
Anonymous says:

This is my first letter as well....just a little over 35 yrs. for me...Type 1....juvenille onset....my first year into this disease I was told a "cure was right around the corner"....I waited and waited and got sicker and sicker .Strikes me as morbid that revenues re: band-aids are now rampant...slimmer more compact models in blood testing monitors are just reely pissing me off....not to mention...that ones medical coverage or income will probably??????just buy you some more Quality (?) time....I've been a lab rat for years!!!!!!!
In order to find the cure one has to admit the" cause" .....And like is that ever going to happen??? It is all really that simple!

posted on Wed, 10/03/2007 - 8:02pm
babyface's picture
babyface says:

hi! i do not have type 1 diabetes but my 24 year old brother does. he has had it for a couple of years now but still has a hard time maintaining a regularity in his blood sugar levels. i would love to have more information on ANY cure possible. thank you!

posted on Wed, 01/10/2007 - 6:21pm
JR's picture
JR says:

When these breakthrough's would be commercially avilable in Asia/India?

posted on Wed, 01/17/2007 - 12:56am
ravinder(india)'s picture
ravinder(india) says:

frnds,i was diagnosed diabetic when i was just 17 year old,those who are diabetic can well understand how difficult it is to live normaly,once i was star performer in each field,then .........now im 34 years old .and no cure still and now worst of all my sweet daughter 4 years old ,recently diagnosed diabetic,now im in great need of cure,otherwise how she will bear the pain of laser treatment for diabetic retinopathy
,im having this time , it is very painfull period for me i cant explain..........

im eagerly waiting for miracle to happen

posted on Thu, 01/18/2007 - 5:04am
Anonymous's picture
Anonymous says:

Have a look at:

http://diabetes.niddk.nih.gov/dm/pubs/pancreaticislet/

This is available at the Mayo Clinic. It is also available in Edmonton where it was perfected.

There are patients who have been up to 5 years without insulin.

posted on Sat, 01/20/2007 - 10:43pm
Anonymous's picture
Anonymous says:

Big companies who make money from suffering will try to block any thing that might interfere with their profits.
The government will continue to support them because of campaign donations.
And the people will contimue to be seen as a manageable cash cow, useful until no longer needed, due to not being able to pay for treaments or funding from above cut, and then, from the postion of business, discarded as soon as is convenient.
So long as business profits are the driving force of any society, dont be suprised when the good of the nobodies of the world are regarded as irrelevent.

posted on Thu, 04/12/2007 - 8:47am
Anonymous's picture
Anonymous says:

Hi My 14 year old son was diagnose with type 1 2 week ago.
does anybody has info how to beat this think.Experiment or anything

posted on Wed, 10/03/2007 - 10:48am
Anonymous's picture
Anonymous says:

i do wish people would be more specific on this thing. i'm sorry about your son.

posted on Wed, 10/03/2007 - 3:10pm
Anonymous's picture
Anonymous says:

My daughter was diagnosed with Type 1 at the age of 18. Now she is 22 and having a cataract removed from her second eye on Friday. She has had a difficult time dealing with everything these past few years, illnesses, ketoacidosis, and finally eye problems. I have watched a healthy teenager who had never had any childhood disease deteriorate into a sickly thin young adult. She was immunized for chicken pox at 13 and meningitis just months prior to developing diabetes. I don't know if certain vaccines can destroy the immune system, but she has had iritis and is being tested for other potential autoimmune diseases. It breaks my heart to see her suffer, and no matter how many times I tell myself there are worse things in life, I know for her there isn't. Like cancer this disease will lead to her death and I am so frightened of the damage this will do to her as she ages especially since it has caused so much damage these past four years. I pray every day for a cure.

posted on Thu, 11/29/2007 - 12:00am
Anonymous's picture
Anonymous says:

i read a artical in " gujarat samachar " indian news papper. dr. h.l. travid in ahmadabad( gujarat city name) dr.h.l.travid breakthurew diabatic by skin stem cell. in news papper he claim a experment on 5 pationt.he is 80 % succeful. price $ 2500. if anybady want to more information about this artical. go to www.gujaratsamachar.com. and ask to news papper.

posted on Thu, 11/29/2007 - 4:10pm
sgt. knapp's picture
sgt. knapp says:

Ya ...diabetes sucks!! i've had it for 10 yrs now..i just turned 40 and fear that my 10 yr old son will fall apart if anything happens to me . He idolizes me so much and loves the fact that ive bee in the army for 13 yrs and went to iraq back in desert storm..Ive been out since 2000 from national guard and my full time term ended in 92. I now make snowmobile tracks and my hands cramp up bad when operating machinery sometimes. I keep feeling depressed when i think about my health . I look fine , i suppose when others look at me...muscular , thinnish , big feet..lol..but i know circulation problems lurk within and i'm deathly scared of a possible fatal heart attack sneaking up on me. Annnny way to speed up that possible cure? Never mind me....millions of kids need immediate care. plssssssssssssssssssss hurry.

posted on Tue, 12/11/2007 - 10:28pm
Mom of a JD (age 23) says's picture
Mom of a JD (age 23) says says:

Never lose HOPE!!! and take your BS frequently!!! It is not fair, I know but you can do it! And 3 cheers to the Toronto scientists, Salter and Dosch for their discoveries--I pray for there continued success frequently. This is so nice because it was Canadian scientists who discovered insulin some 100 years ago!!

posted on Mon, 03/17/2008 - 7:14pm
Life in  box's picture
Life in box says:

http://www.faustmanlab.org/research.html

the link above is a ray of hope...they are currently doing human clinical studies on what they hope will cure diabetes in not only rats, but in humans as well...
i'm cautiously optomisstic....i was diagnosed at the age of 14...i was in a 24 hours coma which they weren't sure in the beginning i was going to even wake up from....it's been rough, but at least i've got my insulin pump and the people i love to help me out...i'm 22 so i've got some time to wait for that cure

posted on Thu, 07/24/2008 - 1:40pm
Anonymous's picture
Anonymous says:

There is a cure........... The money that would be lost from the drug companies wil never allow it to come out....

posted on Mon, 11/17/2008 - 7:04pm
Liza's picture
Liza says:

The increasing prevalence of Type 2 diabetes in the US, unfortunately, makes any treatment for the condition a growth market.

I think, if there WAS a cure, there would be plenty of money to be made from it. I don't buy the conspiracy theories.

posted on Tue, 11/18/2008 - 11:21am
Anonymous's picture
Anonymous says:

This April 2009 it will have been a year since my son was diagnosed with Type 1 Diabetes. He just turned 2 in December. My days and nights are filled with thoughts of my sons future and what he and we will endure. I believe in one thing...regardless of race or religion one should always believe in the almighty. I have hope and nothing can ever diminish that from me. It is infact made stronger when I see the smile in his face and when he plays and laughs with me. Had this happened some 50 plus years ago before they discovered insulin my son along with countless millions would have died. Please for the sake of all involved..especially the children never give up hope. I believe ONE day there will be a cure. Till then may GOD bless each and every one of you and your familes.

posted on Tue, 01/20/2009 - 6:37pm
Jeremy Anderson's picture

Dr Hans-Michael Dosch has been busy, and has filed the above patent.

To summarize: they've identified likely targets for that capsaicin treatment, and suspect that a similar treatment on humans may well be good for several years of non-diabetic bloodsugar in diabetics.

Unfortunately, they had the best results in the mice which were the most recently diagnosed. However, this may give a road to eliminating new cases of diabetes.

posted on Wed, 03/10/2010 - 4:39pm

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