May
24
2009

Genetic analysis of swine flu virus reveals diverse parts

Antigenic shift in flu viruses: is when at least two different strains of a virus combine to form a new subtype having a mixture of the surface antigens of the two original strains.
Antigenic shift in flu viruses: is when at least two different strains of a virus combine to form a new subtype having a mixture of the surface antigens of the two original strains.Courtesy National Institute of Allergy and Infectious Diseases (NIAID)

Model of H1N1 flu virus takes shape

Genetic analysis of the new H1N1 virus shows that the hemagglutinin (the H in H1N1) and two other genes are from the 1918 Spanish flu virus and have been living in pigs ever since. Studies also show that the neuraminidase (the N in H1N1) segment is from the Eurasian swine flu virus that probably leaped from birds to pigs in about 1979.

The new virus differs in 21 of 387 amino acids from the H5N1 virus and the 1918 Spanish flu (also an H1N1 virus). - Singapore’s Agency for Science and Technology Research report in Biology Direct.

Shape shifting viral surface challenges vaccination success

"Viruses isolated from patients during the first two weeks of the current outbreak already have changes on the outer surface on the neuraminidase protein that could interfere with antibodies against the virus or alter the effectiveness of future vaccines. But none of the changes have altered the parts of the protein targeted by antiviral drugs, such as Tamiflu or Relenza." Science News

Learn more
If you click through to the source article in Science News, you will see a great three dimensional model of the influenza A/H1N1 virus with the origin of each of the virus's pieces explained.

Your Comments, Thoughts, Questions, Ideas

Anonymous's picture
Anonymous says:

the swime influenza is a very strange desiese i have never seen anything like it in my 28 years as a doctor.

posted on Mon, 06/22/2009 - 5:26pm
Robin's picture
Robin says:

Swine flu is just influenza. People forget that it is not THAT different from seasonal flu.

Are you really a doctor? Because in 28 years I'm sure you've seen the flu. I also would think that a doctor would know how to spell "disease."

posted on Mon, 06/22/2009 - 7:28pm
Anonymous's picture
Anonymous says:

How deadly is it realy?

posted on Wed, 06/24/2009 - 10:36am

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