Jan
03
2014

Growing younger could be in your future

Aging in reverse gracefully: Scientists are successfully changing old lab mice into young ones.
Aging in reverse gracefully: Scientists are successfully changing old lab mice into young ones.Courtesy Andreas-photography
Bob Dylan first sang about it in the chorus of his 1964 song "My Back Pages" when he wrote ""Ah, but I was so much older then/I'm younger than that now"." He reinforced the notion ten years later when he released "Forever Young" in 1974.

It's all about staying young and not growing old - not ageism mind you - but anti-aging.

In a study appearing in a recent issue of the journal Cell, researchers have successfully reversed the aging process by turning a 2 year-old into one that resembles one that's a mere 6 months old. In human terms this would be equivalent to turning a 60 year-old back into a 20 year-old.

Dr. David Sinclair, professor of genetics at Harvard Medical School, and his team of researchers injected aging mice for a week with a compound known as nicotinamide adenine dinucleotide (NAD+), a natural chemical made from young cells. As mammalian cells age, NAD+ production drops by half causing mitochondrial dysfunction, and the processing of oxygen to fall off. Cells then become vulnerable to the various ailments that aging attracts. But in the treated older mice the cells began to take on the vitality and appearance of young mice.

Sinclair will next try administering NAD+via the drinking water used by lab mice to see how things go . If it has the same effect on the mice's cells, someone call Ponce de Leon because we could be talking about an actual Fountain of Youth!

Since NAD+ is a naturally produced compound, the concern for harmful after-effects is slight. Human trials could begin as early as next year - but it's not going to be cheap - somewhere in the neighborhood of $50,000 a day!

If I win the lottery in the next few months, I'll be first in line to become 20 years-old again, but only if I can retain my experience and any wisdom I may have acquired along the way. But if not, I guess I'll just start humming Dylan's "Knocking on Heaven's Door."

Time magazine story
Guardian story
BBC Health News

Your Comments, Thoughts, Questions, Ideas

stehanie's picture
stehanie says:

that is so awsome that you are a 60 year old and can turn back into a 20 year old!

posted on Sun, 06/08/2014 - 12:09pm

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