Oct
06
2007

Type 2 diabetes discovery

Type 2 diabetes on the rise

Diabetes breakthrough: Genetically modified mice, without PKCe, were fed high fat diets and became fat and insulin resistant but failed to develop diabetes. Instead, they produced extra insulin."
Diabetes breakthrough: Genetically modified mice, without PKCe, were fed high fat diets and became fat and insulin resistant but failed to develop diabetes. Instead, they produced extra insulin."
Diabetes already effects 200 million people world wide. I think the incidence of diabetes is going to sky rocket as the population gets fatter.

Fat molecules reduce the ability of muscle cells to respond to insulin, a phenomenon known as 'insulin resistance'. Most of us cope with this by producing more insulin, but people who develop diabetes can't, probably because fat molecules also disrupt the glucose-sensitive, insulin-producing ('beta') cells in their pancreas.

Why do Type 2 diabetics fail to produce insulin?

An important piece to the diabetes puzzle has been found by researchers at Garvan Institute.

A team from Garvan's Diabetes Signalling Unit, led by Associate Professor Trevor Biden and Dr Carsten Schmitz-Peiffer, has identified an enzyme known as "PKCepsilon" (PKCe) that is active during diabetes and blocks the availability of insulin.

"Our recent research shows that absence of PKCe restores the capacity of the pancreas to produce insulin, a result we were not expecting," said Schmitz-Peiffer.

"In PKCe, we believe we've identified a very important biological target that will enable us to address one of the major underlying causes of diabetes," said Biden.

Their findings have just been published in the prestigious international journal, Cell Metabolism.

Source: Garvan Institute press release

Your Comments, Thoughts, Questions, Ideas

Anonymous's picture
Anonymous says:

A family we know has a diabetic daughter who was on insulin. They tried a fruit juice called Monavie and currently their daughter's insulin intake has been reduced by 75%. This juice is made up of 19 fruits including the Acai berry from Brazil.The Acai Berry’s low glycemic index improves glucose and lipid levels in diabetics. Also in diabetics, weak capillaries can lead to a condition called retinopathy, which often leads to blindness. The Acai berry helps to protect capillaries. The anythocyanins an the acai berry protect small and large vessels, including veins, arteries and capillaries.Learn more: http://www.mymonavie.com/richardwieland

posted on Sat, 10/06/2007 - 8:21pm

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