CT scan showing malignant mesothelioma tumor: a new drug is showing promise against several types of cancer.Courtesy Stevenfruitsmaak via Wikimedia CommonsWhen a cancer cell (a tumor) appears in a particular organ or area of a body, it somehow signals the body's immune system to back off and leave it alone. This allows the cancerous tumor to grow and eventually metastasize to the lymph nodes and other parts of the body. It's as if the cancer grants itself a sort of diplomatic immunity against the body's natural antibodies from interfering with its destructive undertakings.
Now, researchers have found a drug that switches off this "don't touch" warning and allows the cancer to be diminished or entirely destroyed. And it works for several types of cancers, including those affecting the brain, liver, colon, breast, ovary and prostate.
A protein called CD47 is present in human blood cells and prevents those cells from being attacked by the body's immune system. The protein attaches to the surface of the blood cells and signals to the immune system that the blood cells are "okay" and shouldn't be destroyed. About ten years ago, biologist Irving Weissman and researchers at Stanford University's School of Medicine noticed higher levels (up to 3x more) of the same "don't touch" protein were present in leukemia cells, a blood disorder. The surprised Weissman realized that the blood cancer was co-opting the body's own defense system to work against itself, thereby stopping any attacks on the cancer. This left the cancer unmolested and able to grow and spread. After further testing, Weissman and his colleagues subsequently discovered that CD47 levels in many other cancers were also higher than levels in normal cells.
"What we've shown is that CD47 isn't just important on leukemias and lymphomas, it's on every single human primary tumor that we tested.“
The Weissman lab has now developed a promising drug that switches off this "don't touch" signal in cancer cells giving the body's immune system the green light to go after them. The drug has been tested in the laboratory using petri dishes containing treated and untreated cancer molecules. Immune cells (macrophages) were present in each sample. In the untreated sample, the macrophages ignored the cancerous molecules, while they readily attacked those treated with the anti-CD47 drug. In later tests, a variety of human cancer tumors were placed into lab mice and left to grow for two weeks. After the tumors grabbed hold, they were treated with the anti-CD47 therapy and the tumors shrunk considerably or disappeared altogether.
"The microenvironment of a real tumor is quite a bit more complicated than the microenvironment of a transplanted tumor," Weissman said, "and it's possible that a real tumor has additional immune suppressing effects."
The biologist is confident that the research will eventually move into human clinical trials within the next two years.
SOURCES and LINKS
Sciencemag.org
Stanford news
Nature World News
What are antibodies
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Non-robotic jellyfish: Engineering researchers at Virginia Tech are building robots that mimic the efficient way jellyfish get around.Courtesy Andy Field (Field Offie)Researchers at Virginia Tech are working on several versions of robotic jellyfish that someday could be used by the military, or for mapping the ocean floor, or cleaning up oil spills.
Known affectionately as RoboJelly, the silicone blobs range from the size of a baseball to a giant five-foot floating monster. Each mimics the swimming technique used by jellyfish, those huffing and puffing water-bags that populate the world's oceans.
In nature, most jellyfish propel themselves by the seemingly simple expansion and contraction of their umbrella, using it to push water out like a rocket blast that propels it forward. But the fluid dynamics are a little more complicated than than just expelling out a big blast of water and moving the other way. It's more like when your cigar-smoking uncle would blow smoke rings into the air to impress you. Remember that? I do. These are called vortex rings, and it's the efficiency of the hydromedusean's self-created fluid flow that interest the VT researchers.
Students at VT's College of Engineering use thin layers of silicone - the same material used for swimming masks - to construct the robots. Electric batteries in watertight plexiglass boxes are used to power the mechanical blobs. The researchers are also looking into ways of extracting hydrogen from water to power them.
“Nature has done great job in designing propulsion systems but it is slow and tedious process," said Shashank Priya, associate professor at Virginia Tech, and the project's lead researcher. "On the other hand, current status of technology allows us to create high performance systems in a matter of few months.”
The on-going project involves a number of U.S. universities and industries, and will warrant several additional years of research before any prototypes are released for use. Besides possible military application, RoboJelly could be employed for such things as monitoring ocean currents and conditions, cleaning up oil spills, and studying sea-bottom flora and fauna.
Talk about microcinema - watch this incredibly teeny-tiny movie (the world's smallest) that researchers at IBM created by manipulating single atoms of carbon monoxide molecules in a scanning tunneling microscope. Then watch how it was made. It's an incredible accomplishment considering the atoms used to create the animation had to be magnified 100 million times!
Edging toward space: SpaceShipTwo took a little step in getting closer to reaching space today.Courtesy Virgin GalacticThis morning high above the Mojave Desert in California, SpaceShipTwo fired its engines in air for the first time, making its first step toward putting a commercial, tourist space craft into space. As opposed to traditional ground-fired rockets, SpaceShipTwo is carried up into the upper atmosphere by a jet plane, cut loose and then fires its engines to boost it toward space. Today's test took the craft up to 45,000 feet with its partner. The blast shoot it up to 55,000 feet for about a 10 minutes. Here is a link to video of the firing. And here is a link to our previous posts about SpaceShipTwo.
Coelacanth: model in the SMM paleo lab. Photo by Mark Ryan.Courtesy Fancy Horse (underwater background)The genome of the coelacanth, the world's best known living fossil, has been sequenced by an international team of researchers and is revealing something scientists already suspected: that the primitive-looking fish has evolved more slowly than most other organisms. The coelacanth is related to the lungfish and several extinct Devonian fish species that are considered precursors to land dwelling tetrapods. Kerstin Lindblad-Toh is senior author of the study which appeared recently in the science journal Nature.
"We often talk about how species have changed over time, but there are still a few places on Earth where organisms don't have to change, and this is one of them," Lindblad-Toh said. "Coelacanths are likely very specialized to such a specific, non-changing, extreme environment -- it is ideally suited to the deep sea just the way it is."
Lindblad-Toh is scientific director of the Broad Institute's vertebrate genome biology group in Cambridge, Massachusetts, which did the genome research. The institute is linked to both MIT and Harvard.
The genetic map, which involved sequencing some 3 billion letters of DNA, also showed (via RNA content) that tetrapods - four-legged land dwelling animals - though related to both coelacanths and lungfish, are more closely related to lungfish and followed that line rather than that of the coelacanth. We humans also branched off that same line. The genome of a lungfish is composed of over 100 billion DNA letters, making it a much more difficult task to sequence, so for the time being, the coelacanth's DNA makes for a reasonable alternative for study.
"This is just the beginning of many analyses on what the coelacanth can teach us about the emergence of land vertebrates, including humans, and, combined with modern empirical approaches, can lend insights into the mechanisms that have contributed to major evolutionary innovations," said professor Chris Amemiya at the University of Washington, and the paper's co-author.
Fossil coelacanth: not much has changed in 350 million years.Courtesy photo by Haplochromis via Wikipedia Creative CommonsWhen Louis Agassiz named the first fossil coelacanth back in 1836, the Swiss paleontologist probably never imagined that a nearly identical descendent of the primitively constructed Devonian-aged fish would one day be found still inhabiting the world's oceans. The coelacanth was thought to have gone extinct along with the non-avian dinosaurs at the end of the Cretaceous period. None have been found in the fossil record after that time, but two extant species are known today. The first specimen Latimeria chalumnae was netted off the coast of South Africa in 1938, near the Chalumnae river and retrieved by East London Museum curator Marjorie Courtenay-Latimer who discovered what she called "the most beautiful fish I'd ever seen" in the catch of local fisherman, Henrik Goosen. Since then several more coelacanths have been caught, including the Indonesian species, Latimeria menadoensis, from the Indian Ocean.
The remarkable prehistoric throw-back, sometimes referred to as "old four legs" because of its leg-like fins, hasn't changed much in its 350 million year history. A member of the clade of lobe-finned fishes called Sarcopterygii, coelacanths retain primitive characteristics such a notochord, a hollow fluid-filled tube made of cartilage that underlies the spine over the length of its body. In all other vertebrates, the notochord is an anatomical structure that appears briefly only during the embryonic stage but not in adults. Not so with the coelacanth. It also possesses, primitive shark-like intestines, a linear heart, and tightly-woven armor-like scales (known as cosmoid) that are only found on extinct species of fish. The coelacanth's brain case contains only 1.5 percent gray matter - the other 98.5 percent of space is filled with fat. The other end of the coelacanth body begins to taper before expanding into a strange, three-lobed tail. Its most notable features are its lobed pectoral and pelvic fins that are structured with bones that look like toes, and move in an alternating tetrapod manner. An electroreceptive rostal organ located in its snout is used to detect prey, and the coelacanth is the only living animal that can unhinge a section of the its cranium to increase the gape of its mouth, enabling it to consume larger prey.
The blue or brown, white-speckled coelacanths prefer deep-water environments, and can reach six and a half feet in length and weigh upwards to 175 pounds. For some reason no living coelacanth has managed to survive more than a single day in captivity. With a dwindling population estimated at only 500-1000 individuals, the coelacanth was declared an endangered species in 1989.
SOURCE and LINKS
Broad Institute news
Coelacanth info at dinofish.com
More coelacanth info
NatGeo article
Take Nova's Coelacanth Quiz
Unlike US air travelers, sequestration doesn't seem to be causing any problems for buzzing honey bees. Check out this cool Bee in ultra slow motion video from Joris Schaap on Vimeo.The ultra slow-motion clip came to my attention via EarhSky.org. Here's what the site had to say about it:
Scientists say that the secret of honeybee flight is a combination of short, choppy wing strokes, a rapid rotation of the wing as it flops over and reverses direction, and a very fast wing-beat frequency. Wing-beat frequency normally increases as body size decreases, but as the bee’s wing beat covers such a small arc, it flaps approximately 230 times per second, faster than a fruitfly (200 times per second) which is 80 times smaller.
The video was shot at 3000 frames per second (!) and is part of something called Flightartist Project, which you can take part in if you're so inclined. Check out the project site for further information (you'll need to speak Dutch or somehow translate it).
Nabbing terrorists: Robotics experts are analyzing how automated devices played a part in apprehending the Boston Marathon bombers.Courtesy MashableLaw enforcement authorities aren't giving out specific information, but robotic experts are chiming in with their thoughts on how robots played a role in capturing the Boston Marathon bombers. Here's a pretty interesting online article theorizing the use of robots in the case. The link includes a video that shows how these robots do their jobs. While TV reports Friday night said that a robotic arm was used to pull the tarp off the boat where the second suspect was hiding, those reports, have now been called incorrect.
What do you think about using robots to handle dangerous tasks involving terrorism and crime?
I feel like there should be some whacky music or pun-filled intro a la America's Funniest Videos, but we'll let this video just stand on its own.
People from all walks of life are fascinated by weather and make routine measurements. The “Cooperative Network” operated by the National Weather Service (or NWS) is a network of several thousand volunteers from across the country that routinely make and report weather observations. This Coop has operated continuously since 1890. The group includes about 9,000 weather observes who systematically measure high and low temperatures, rainfall and snow accumulation every day. These observations are archived at the National Climatic Data Center and are a large part of the historical weather record of the country.
Another group, the Community Collaborative Rain, Hail and Snow networks, or CoCoRaHS, includes 15,000 volunteers who help measure and report precipitation type and amounts every day. Observations of precipitation by a large group of volunteers are critical to understanding storms as precipitation varies widely from place to place even in a single storm. Such observations are useful for assessing flooding hazards and rapid snow melting. You can join CoCoRaHS at http://www.cocorahs.org.
There are also tens of thousands of citizens that serve as NWS severe weather spotters. The NWS relies on these storm spotters, along with radars, satellites and other data to supply observations that help in NWS’ decision making process of issuing and verifying severe weather warnings. The NWS is always looking for volunteers to help get the word out about severe storms. You can find out more about this group and sign up for classes and become a trained spotter at http://www.crh.noaa.gov/mkx/?n=spotters. It is a good class to take as we approach severe weather season.
So, if you enjoy making weather observations, join one of these groups and be one of the nation's weather observers!
Tall order: Scientists are cloning giant redwood trees from California in an effort to reforest lost trees and combat climate change.Courtesy VictorgrigasStart talking about giant cloning projects, and the conversation is going to quickly turn to Jurassic Park, the film that "what iffed" the cloning of dinosaurs. It was all for fun, if beyond hypothetical.
But giants of another kind, trees, are being cloned in an effort to help turn the balance of deteriorating conditions here on Earth. California's iconic, and incredibly tall, redwood trees are getting the cloning treatment. You can read the full details about the project here. And today, Earth Day 2013, the project is going global as clones of these redwoods are being planted in Australia, New Zealand, Great Britain, Ireland, Canada, Germany and the U.S.
Why clone just behemoth trees? The guys running the project surmise where better to find the strongest, hardiest genetic codes to withstand the coming climate pressures than in these huge redwoods, many which have lived for over 4,000 years.
The current crop of plantings come from the DNA of giant trees cut down about a century ago. Even though the bulk of the trees are just stumps today, those stumps are very much alive. They have live shoots emerging from the stumps, which the researchers can extract DNA from to serve as the basis for their cloning work.
The new plantings have a long way to go. They're only about 18 inches tall right now. The big challenge, the researchers say, is to find people and resources to nurture this little trees into viable, independent growers.
Redwoods are considered best suited to absorb massive volumes of carbon dioxide, the greenhouse gas primarily responsible for climate change.
What do you think? Is this a good application for cloning? Can these huge trees make a difference with climate change over the long haul? Should we be tinkering around with this kind of science?
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