Courtesy Rev Dan CattA new study just published in the Journal of Biological Chemistry says our third molars - aka wisdom teeth - could serve as an excellent source for stem cells. Rather than yanking them out and discarding them (often under our pillows), the molars could be kept as a repository of stem cells for our own use in regenerative medicine. The Japanese study, which was led by Yasuaki Oda, states cloned cells derived from wisdom teeth closely resemble embryonic stem cells.
It sounds like wise use of what's otherwise considered medical waste, but don't be surprised if the Tooth Fairies' Union says it bites.
Courtesy be_khe A person with diabetes cannot make insulin so insulin needs to be injected at the proper time and amount. Transplanting insulin producing cells called islets may solve the need for insulin injections. Transplanting human islet cells requires an appropriate donor and a lifetime of anti-rejection drugs. Not good.
Before 1980 insulin from pigs allowed people with diabetes to survive. Pig heart valves transplants also worked out in humans.
Scientists recently injected embryonic pig pancreatic cells into rats which grew to became the pancreas, which houses the islet cells that produce insulin. Eight weeks later islet cells from adult pigs were transplanted into that pancreatic tissue and were not rejected
The new research -- the first long-term, successful cross-species transplant of pig islets without immune suppression -- raises the prospect that it may one day be possible to cure diabetes in humans using a similar strategy. Science Dailey
Marc Hammerman and his colleagues at Washington University School of Medicine in St. Louis are now beginning experimentation using the same methods on non-human primates.
Cut spinal cords, destroyed brain tissue, or damaged heart muscle can be repaired by injecting stem cells into the damaged area. Embryonic stem (ES) cells are like blank cells that give rise to every type of cell and tissue in the body. Using human embryos or unfertilized human eggs as a source of stem cells raised show-stopping opposition. Now stem cells have been produced from skin.
Two separate teams of researchers announced on Tuesday they had transformed ordinary skin cells into batches of cells that look and act like embryonic stem cells -- but without using cloning technology and without making embryos.
Both teams call the new cells induced pluripotent stem (iPS) cells and say they look and act like embryonic stem cells.
The research was published online Tuesday by two journals, Cell and Science. The Cell paper is from a team led by Dr. Shinya Yamanaka of Kyoto University; the team published by Science was led by Junying Yu, working in the lab of stem-cell pioneer James Thomson of the University of Wisconsin-Madison.
Thompson said the technique is so simple that "thousands of labs in the United States can do this, basically tomorrow." In contrast, the cloning approach is so complex and expensive that many scientists say it couldn't be used routinely to supply stem cells for therapy.