Scientists have found a small molecule that can be used to extend the lifespan of mammalian cells. The research reported in the July issue of Nature Chemical Biology showed that the synthetic organic molecule CGK733 blocks the machinery that senses DNA damage. They found that CGK733 could extend the lifetime of cultured cells by about 20 doublings and could actually rescue cells that were already senescent. Senescent cells are cells that can stay alive but have stopped dividing.
Prof. Kim Tae-kook at the Korea Advanced Institute of Science and Technology and his associates developed a technology dubbed MAGIC, short for magnetism-based interactive capture. This state-of-the-art magnetic nano-probe technology uses fluorescent materials to check whether any drug can mix with targeted proteins inside the cell.
Read more in The Korea Times or in Nature Chemical Biology press release and abstract.