Courtesy Stevenfruitsmaak via Wikimedia CommonsWhen a cancer cell (a tumor) appears in a particular organ or area of a body, it somehow signals the body's immune system to back off and leave it alone. This allows the cancerous tumor to grow and eventually metastasize to the lymph nodes and other parts of the body. It's as if the cancer grants itself a sort of diplomatic immunity against the body's natural antibodies from interfering with its destructive undertakings.
Now, researchers have found a drug that switches off this "don't touch" warning and allows the cancer to be diminished or entirely destroyed. And it works for several types of cancers, including those affecting the brain, liver, colon, breast, ovary and prostate.
A protein called CD47 is present in human blood cells and prevents those cells from being attacked by the body's immune system. The protein attaches to the surface of the blood cells and signals to the immune system that the blood cells are "okay" and shouldn't be destroyed. About ten years ago, biologist Irving Weissman and researchers at Stanford University's School of Medicine noticed higher levels (up to 3x more) of the same "don't touch" protein were present in leukemia cells, a blood disorder. The surprised Weissman realized that the blood cancer was co-opting the body's own defense system to work against itself, thereby stopping any attacks on the cancer. This left the cancer unmolested and able to grow and spread. After further testing, Weissman and his colleagues subsequently discovered that CD47 levels in many other cancers were also higher than levels in normal cells.
"What we've shown is that CD47 isn't just important on leukemias and lymphomas, it's on every single human primary tumor that we tested.“
The Weissman lab has now developed a promising drug that switches off this "don't touch" signal in cancer cells giving the body's immune system the green light to go after them. The drug has been tested in the laboratory using petri dishes containing treated and untreated cancer molecules. Immune cells (macrophages) were present in each sample. In the untreated sample, the macrophages ignored the cancerous molecules, while they readily attacked those treated with the anti-CD47 drug. In later tests, a variety of human cancer tumors were placed into lab mice and left to grow for two weeks. After the tumors grabbed hold, they were treated with the anti-CD47 therapy and the tumors shrunk considerably or disappeared altogether.
"The microenvironment of a real tumor is quite a bit more complicated than the microenvironment of a transplanted tumor," Weissman said, "and it's possible that a real tumor has additional immune suppressing effects."
The biologist is confident that the research will eventually move into human clinical trials within the next two years.
Courtesy Andy Field (Field Offie)Researchers at Virginia Tech are working on several versions of robotic jellyfish that someday could be used by the military, or for mapping the ocean floor, or cleaning up oil spills.
Known affectionately as RoboJelly, the silicone blobs range from the size of a baseball to a giant five-foot floating monster. Each mimics the swimming technique used by jellyfish, those huffing and puffing water-bags that populate the world's oceans.
In nature, most jellyfish propel themselves by the seemingly simple expansion and contraction of their umbrella, using it to push water out like a rocket blast that propels it forward. But the fluid dynamics are a little more complicated than than just expelling out a big blast of water and moving the other way. It's more like when your cigar-smoking uncle would blow smoke rings into the air to impress you. Remember that? I do. These are called vortex rings, and it's the efficiency of the hydromedusean's self-created fluid flow that interest the VT researchers.
Students at VT's College of Engineering use thin layers of silicone - the same material used for swimming masks - to construct the robots. Electric batteries in watertight plexiglass boxes are used to power the mechanical blobs. The researchers are also looking into ways of extracting hydrogen from water to power them.
“Nature has done great job in designing propulsion systems but it is slow and tedious process," said Shashank Priya, associate professor at Virginia Tech, and the project's lead researcher. "On the other hand, current status of technology allows us to create high performance systems in a matter of few months.”
The on-going project involves a number of U.S. universities and industries, and will warrant several additional years of research before any prototypes are released for use. Besides possible military application, RoboJelly could be employed for such things as monitoring ocean currents and conditions, cleaning up oil spills, and studying sea-bottom flora and fauna.
Courtesy Fancy Horse (underwater background)The genome of the coelacanth, the world's best known living fossil, has been sequenced by an international team of researchers and is revealing something scientists already suspected: that the primitive-looking fish has evolved more slowly than most other organisms. The coelacanth is related to the lungfish and several extinct Devonian fish species that are considered precursors to land dwelling tetrapods. Kerstin Lindblad-Toh is senior author of the study which appeared recently in the science journal Nature.
"We often talk about how species have changed over time, but there are still a few places on Earth where organisms don't have to change, and this is one of them," Lindblad-Toh said. "Coelacanths are likely very specialized to such a specific, non-changing, extreme environment -- it is ideally suited to the deep sea just the way it is."
Lindblad-Toh is scientific director of the Broad Institute's vertebrate genome biology group in Cambridge, Massachusetts, which did the genome research. The institute is linked to both MIT and Harvard.
The genetic map, which involved sequencing some 3 billion letters of DNA, also showed (via RNA content) that tetrapods - four-legged land dwelling animals - though related to both coelacanths and lungfish, are more closely related to lungfish and followed that line rather than that of the coelacanth. We humans also branched off that same line. The genome of a lungfish is composed of over 100 billion DNA letters, making it a much more difficult task to sequence, so for the time being, the coelacanth's DNA makes for a reasonable alternative for study.
"This is just the beginning of many analyses on what the coelacanth can teach us about the emergence of land vertebrates, including humans, and, combined with modern empirical approaches, can lend insights into the mechanisms that have contributed to major evolutionary innovations," said professor Chris Amemiya at the University of Washington, and the paper's co-author.
Courtesy photo by Haplochromis via Wikipedia Creative CommonsWhen Louis Agassiz named the first fossil coelacanth back in 1836, the Swiss paleontologist probably never imagined that a nearly identical descendent of the primitively constructed Devonian-aged fish would one day be found still inhabiting the world's oceans. The coelacanth was thought to have gone extinct along with the non-avian dinosaurs at the end of the Cretaceous period. None have been found in the fossil record after that time, but two extant species are known today. The first specimen Latimeria chalumnae was netted off the coast of South Africa in 1938, near the Chalumnae river and retrieved by East London Museum curator Marjorie Courtenay-Latimer who discovered what she called "the most beautiful fish I'd ever seen" in the catch of local fisherman, Henrik Goosen. Since then several more coelacanths have been caught, including the Indonesian species, Latimeria menadoensis, from the Indian Ocean.
The remarkable prehistoric throw-back, sometimes referred to as "old four legs" because of its leg-like fins, hasn't changed much in its 350 million year history. A member of the clade of lobe-finned fishes called Sarcopterygii, coelacanths retain primitive characteristics such a notochord, a hollow fluid-filled tube made of cartilage that underlies the spine over the length of its body. In all other vertebrates, the notochord is an anatomical structure that appears briefly only during the embryonic stage but not in adults. Not so with the coelacanth. It also possesses, primitive shark-like intestines, a linear heart, and tightly-woven armor-like scales (known as cosmoid) that are only found on extinct species of fish. The coelacanth's brain case contains only 1.5 percent gray matter - the other 98.5 percent of space is filled with fat. The other end of the coelacanth body begins to taper before expanding into a strange, three-lobed tail. Its most notable features are its lobed pectoral and pelvic fins that are structured with bones that look like toes, and move in an alternating tetrapod manner. An electroreceptive rostal organ located in its snout is used to detect prey, and the coelacanth is the only living animal that can unhinge a section of the its cranium to increase the gape of its mouth, enabling it to consume larger prey.
The blue or brown, white-speckled coelacanths prefer deep-water environments, and can reach six and a half feet in length and weigh upwards to 175 pounds. For some reason no living coelacanth has managed to survive more than a single day in captivity. With a dwindling population estimated at only 500-1000 individuals, the coelacanth was declared an endangered species in 1989.
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Courtesy Terence OngIn one of the biggest breakthroughs in food and dietary history, the U.S. Food and Drug Administration has announced today (April 1, 2013), that it is permitting the sale of genetically modified ice cream to the public. The announcement comes on the heals of 16 years of experimenting and testing to come with a healthier version of the dairy food.
"Through the genetic modification (GM) process, we've been able to remove up to 93 percent of the calories you find in traditional ice creams, explained FDA spokesman Herman Guernsey. "And with that breakthrough, we've eliminated 100 percent of the guilt associated with eating ice cream. Now, people will be able to enjoy healthier and happier ice cream."
Of course, such breakthroughs also require some significant changes to the ice cream. The GM process did not work for traditional ice cream flavors like vanilla, chocolate or strawberry. "We did have to turn to some more health-oriented flavorings, but our focus groups seemed to especially like the GM ice cream flavors of broccoli, spinach and tuna," said Guernsey.
Cost is another issue for consumers. In order to push the GM ice cream through this advanced process, the cost right now is about $10 a pint. While public sales start today, GM ice cream may not be available in all grocery stores. But internet orders are being accepted at the website www.gmicecream.com. "We strongly advise anyone making internet orders do do so in the winter time as the ice cream is shipped by U.S. mail," Guernsey added.
He concluded: "We think people will enjoy this new GM ice cream and have a good laugh while reading this blog post."
We've all seen them, those great B-films where a giant, vicious monster from under the sea, or invaders from outer space arrive to cause mayhem across our cities and generally mess up our way of life. In the end, it seems no matter who or what it was that was attacking us, be it Mothra, Godzilla, or some race of belligerent extra-terrestrials, we could always count on the military to save our collective behind.
Unfortunately, with mosquitoes, that might now be the case anymore.
Scientists are reporting that Deet, one of the most widely used active ingredients in insect repellents, loses its effectiveness against mosquitoes shortly after those ubiquitous, blood-seeking winged vermin are first exposed to it.
Deet - the common name for N,N-diethyl-meta-toluamide - was developed by the US Army after the Second World War to help combat insects during jungle warfare. It was used extensively in the Korean and Vietnam wars, but mosquitoes seem to be able to adapt quickly to it.
"Mosquitoes are very good at evolving very very quickly", said Dr. James Logan of the London School of Hygiene and Tropical Medicine and co-author of the study. "There is something about being exposed to the chemical that first time that changes their olfactory system - changes their sense of smell - and their ability to smell Deet, which makes it less effective."
So what I want to know is where does that leave us here in Minnesota where the mosquito constantly competes with the Common Loon for the title of State Bird? Maybe it's time to start digging the bunker in the backyard.
Courtesy Mark RyanA cat in Florida got loose on one side of the state and managed to find its way back home to the other side, baffling both the delighted owners and scientists. Holly, the directionally-savvy 4-year-old tortoiseshell cat traveled from Daytona Beach to within a mile of her owners’ home in West Palm Beach. It took her about 50 days to traverse the 200 mile distance. When found, the poor kitty was weak and emaciated, had a croaky meow, and displayed signs of hoofing it over long distances.
“Her pads on her feet were bleeding,” said Bonnie Richter, who along with her husband, Jacob, are the happy owners (read: service staff) of the migratory feline. “Her claws are worn weird. The front ones are really sharp, the back ones worn down to nothing.
Skeptics might conjecture that the found cat is merely a stray that just looks like the long-lost Holly, and that the distraught owners only think it’s their cat because they miss her so and want to believe it’s her. Well, they couldn’t be more wrong. The scruffy cat in question had an implanted microchip that proves it is indeed Holly.
The Richters’ tale is but one of many incredible stories about lost or separated pets finding their way back home across vast distances. And surprisingly, science doesn’t seem to have any answers as how the animals do it.
“I really believe these stories, but they’re just hard to explain,” said Marc Bekoff, a behavioral ecologist at the University of Colorado. “Maybe being street-smart, maybe reading animal cues, maybe being able to read cars, maybe being a good hunter. I have no data for this.”
New York Times story
Courtesy rijksbandradio (original image) via Flckr; graphic by author.By now most readers are aware of the double helix, the two intertwined ribbons of genetic information that make up our DNA.
Now researchers at University of Cambridge have announced the discovery of a quadruple helix in the human genome. The four-stranded genetic ribbons are termed G-quadruplexes because they contain high levels of the nucleotide guanine (the other 3 nucleotides are adenine, thymine, and cytosine – together they make up the G, A, T, and C elements of DNA; uracil (U) replaces thymine in RNA). G-quadruplexes mainly appear at the moment of cell replication, when cells divide and multiply. Researchers think this indicates that G-quadruplexes are an essential part of the replication process. The upsurge of G-quadrupleexes was detected using fluorescent biomarkers. The discovery could open up new avenues in the treatment of cancer
"The research indicates that quadruplexes are more likely to occur in genes of cells that are rapidly dividing, such as cancer cells,” said Shankar Balasubramanian, the study’s lead researcher. “For us, it strongly supports a new paradigm to be investigated -- using these four-stranded structures as targets for personalised treatments in the future."
Balasubramanian, a professor at the Department of Chemistry and Cambridge Research Institute, thinks synthetic molecules could one day be used to corral the G-quadruplexes and hinder the out-of-control cell division often prevalent in cancerous cells. In fact, the research team has already been successful in slowing down the replication process by using such molecules. During their experiments, when cell division was blocked, the number of G-quadruplexes decreased.
The research was published in Nature Chemistry. The 'quadruple helix' discovery comes 60 years after the discovery of the double helix in 1953, also at the University of Cambridge.
Courtesy Jeremie63Chemists from the University of Massachusetts Amherst have developed a way to quickly and accurately detect and identify metastatic cancer cells in living tissue, in much the same way that your nose can detect and identify certain odors.
The smell of a rose, for example, is a unique pattern of molecules, which activates a certain set of receptors in your nose. When these specific receptors are triggered, your brain immediately recognizes it as a rose.
Similarly, each type of cancer has a unique pattern to the proteins that make up its cells. The Amherst chemists just needed a "nose" to recognize these patterns. What they came up with was an array of gold nanoparticle sensors, coupled with green fluorescent proteins (GFP). The researchers took healthy tissue and tumor samples from mice, and trained the nanoparticle-GFP sensors to recognize the bad cells, and for the GFP to fluoresce in the presence of metastatic tissues.
This method is really sensitive to subtle differences, it's quick (can detect cancer cells within minutes), it can differentiate between types of cancers, and is minimally invasive. The researchers haven't tested this method on human tissue samples yet, but it holds some exciting potential.
Courtesy NISE NetworkWhen things get really really small (nanoscale small), they behave completely differently! For example, gold at the nanoscale can look purple, orange, or red; static electricity has a greater effect on nanoparticles than gravity; and aluminum (the stuff your benign soda cans are made of) is explosive at the nanoscale!
If you want to experience some of these nanoscale phenomena first-hand, check out whatisnano.org, or download the DIY Nano app. The website and the app were both created by the Nanoscale Informal Science Education Network (NISE Net for short), and have videos and activity guides, complete with instructions and material lists, so you can do some nano experiments at home! The app was a Parents' Choice award winner for 2012, and was featured in Wired Magazine's review of apps. Definitely worth a look!
Have fun exploring nanoscale properties!