Stories tagged Burdelya

Apr
20
2008

Defense against deadly doses of radiation

Radiation defense
Radiation defenseCourtesy Fibonacci
Whether by nuclear accident, radiation treatment, or a dirty bomb, exposure to formerly deadly doses of radiation now might be survivable. Cleveland Biolabs, Inc. (CBLI) has a compound called Protectan that has rescued mammals from lethal doses of radiation. The effectiveness of Protectans whether injected before or after radiation exposure indicates that these compounds have great potential as practical, as well as effective and non-toxic, biodefense measures.

Why is radiation deadly?

The lethality of high dose ionizing radiation is largely due to development of Acute Radiation Syndrome (ARS) caused by massive apoptosis in radiosensitive organs, including:

  • intestinal cells (leading to nausea)
  • hair follicles (leading to hair loss)
  • spermatocytes (leading to male infertility)
  • hematopoietic (HP) cells (leading to immunosuppression)

How antiradiation pharmaceuticals work

Cleveland Biolabs, Inc. is currently developing derivatives of microbial factors that are natural regulators of apoptosis. Click here for a more complete discussion of how Protactan's work as radiation antidotes.

  • Protectan CBLB502 is a rationally designed recombinant derivative of the bacterial protein, flagellin, which binds and activates the mammalian TLR5 cell surface receptor. Moreover, TLR5 is expressed on the endothelial cells of the small intestine lamina propria, the most radiosensitive part of the GI tract
  • CBLB600 Series Protectans are synthetic derivatives of mycoplasma lipopeptide, which promote activation of the anti-apoptotic NF-kappaB pathway associated with acute radiation syndrome

Here is a link to the research paper in Science titled
An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models
More research papers can be accessed at CBLI Publications